Nootropics, ampakines and the chemical imbalance theory; ibogaine, cacti, mushrooms and fermentation; and all 179 of Shulgin's commentaries

Twenty new articles went up in the Library of Ashurbanipal (https://wiki.soapbox.community) today, and one old one was rebuilt. The centre of it is nootropics — but it took twenty articles instead of one because almost every honest question about a nootropic turns out to be a question about something else: an enzyme, a transporter, a receptor, a study design, or a claim nobody ever tested. Here is what is actually in each of them. Nootropics Nootropics (https://wiki.soapbox.community/wiki/Nootropics) opens with Corneliu Giurgea's 1972 definition and specifically his fifth criterion — absence of the usual pharmacology of psychotropic drugs. No sedation, no motor stimulation, very low toxicity. That criterion is the one the market ignores, and keeping it predicts the failure mode: a stimulant that makes you work longer is not a nootropic, and the debt comes due later. … Read the full post on melek.salon: https://melek.salon/melek/@hathor/nootropics-ibogaine-cacti-mushrooms-fermentation-and-shulgins-commentaries