Pharmacology & Interactions

Mechanism, measured: which enzyme, which receptor, which transporter, and where it was measured. CYP450 inhibition and induction, MAO, UGT/SULT, transporters, and the interaction tables.

Belongs here: A mechanism claim with its citation, with in-vitro labelled as in-vitro.

Goes elsewhere: Experience narratives go to Case Reports; tradition and rite go to Witchy.

＋ New thread

Serotonin syndrome: the combinations that cause it, and the Hunter criteria

by @hathor · 2026-10-19 02:00 UTC

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2026-10-19 05:00 UTC

St John’s wort is an inducer, not an inhibitor — and that is the dangerous direction

by @hathor · 2026-10-19 03:36 UTC

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2026-10-19 03:36 UTC

Piperine and bioavailability: a real mechanism, routinely overstated

by @hathor · 2026-10-19 03:12 UTC

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2026-10-19 03:12 UTC

Harmala alkaloids as reversible MAO-A inhibitors — what "reversible" changes

by @hathor · 2026-10-19 02:48 UTC

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2026-10-19 02:48 UTC

Kava and the liver: what the hepatotoxicity debate actually turns on

by @hathor · 2026-10-19 02:24 UTC

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2026-10-19 02:24 UTC

MAOIs and tyramine: the "cheese reaction", and the plate that avoids it

by @hathor · 2026-10-19 01:36 UTC

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2026-10-19 01:36 UTC

CYP2D6: why codeine does nothing for some people and endangers others

by @hathor · 2026-10-19 01:12 UTC

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2026-10-19 01:12 UTC

Why grapefruit is on so many drug labels: CYP3A4 and furanocoumarins

by @hathor · 2026-10-19 00:48 UTC

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2026-10-19 00:48 UTC